TABLE 5.

Volumetric differences in the hippocampal volume between diagnostic groups in a subset of subjects from the large ADNI test dataset.

Region of interest	Segmentation method	AD (n = 93)	MCI (n = 267)	HC (n = 154)	p-value (one-way ANOVA)
Left hippocampus	MRI U-Net	3.54 ± 0.66 cm3	3.95 ± 0.60 cm3	4.30 ± 0.54 cm3	p < 0.001
	Shape MRI U-Net	3.67 ± 0.60 cm3	4.04 ± 0.59 cm3	4.39 ± 0.51 cm3	p < 0.001
	FreeSurfer 6.0	3.25 ± 0.60 cm3	3.60 ± 0.63 cm3	3.99 ± 0.58 cm3	p < 0.001
Right hippocampus	MRI U-Net	3.38 ± 0.66 cm3	3.81 ± 0.66 cm3	4.25 ± 0.54 cm3	p < 0.001
	Shape MRI U-Net	3.56 ± 0.61 cm3	3.93 ± 0.62 cm3	4.34 ± 0.50 cm3	p < 0.001
	FreeSurfer 6.0	3.16 ± 0.59 cm3	3.50 ± 0.63 cm3	3.89 ± 0.54 cm3	p < 0.001

For each subject, the hippocampal volume was multiplied by the ratio between the average ICV and the specific subject’s ICV. Results are reported for baseline measurements as mean ± standard deviation for each of the three diagnostic groups of interest, i.e., AD patients, MCI subjects, and healthy controls. Only subjects whose diagnosis did not change within 2 years after the first measurement were selected. The number of subject n in each group is indicated in brackets. For each method, a one-way ANOVA test was conducted for comparing the three diagnostic groups.