TABLE 1.
Summary of CC50, EC50, and SI values of the compounds against BIRFLU during posttreatment in MDCK cellsa
| Compound | Activity statistics of compound against BIRFLUb
|
||||
|---|---|---|---|---|---|
| CC50 (MTT) (μM) | CC50 (XTT) | EC50 | SI (MTT) | SI (XTT) | |
| AmA | >50.00 | <2.54 nM | 3.80 nM | >13,157.89 | <0.66 |
| BRQ | >50.00 | >50.00 μM | 0.58 μM | >86.21 | >86.21 |
| 6-Azauridine | 42.66 | >50.00 μM | 0.34 μM | 125.47 | >147.06 |
| Azaribine | 19.66 | >50.00 μM | 0.29 μM | 67.79 | >172.41 |
| PF | 33.35 | >50.00 μM | 38.90 nM | 857.33 | >1,285.35 |
| AVN-944 | 29.61 | >50.00 μM | 0.21 μM | 141.00 | >238.10 |
| MMF | >50.00 | >50.00 μM | 0.77 μM | >64.94 | >64.94 |
| MPA | >50.00 | >50.00 μM | 1.73 μM | >28.90 | >28.90 |
| Obatoclax | 0.23 | 15.43 μM | 0.42 μM | 0.55 | 36.74 |
| Osu-03012 | 7.50 | 46.09 μM | 14.42 μM | 0.52 | 3.20 |
| Ribavirin | >50.00 | >50.00 μM | 9.50 μM | >5.26 | >5.26 |
a
BIRFLU, A/Puerto Rico/8/34 H1N1.
b
CC50, median 50% cytotoxicity concentration; EC50, median 50% effective concentration; SI, selective index (CC50/EC50).