TABLE 4.
Summary of CC50, EC50, and SI values of the compounds against seasonal H1N1 and H3N2 IAVs and IBV during posttreatment in MDCK cells
| Virusa | Compound | Activity statistics of compound against virusb
|
||||
|---|---|---|---|---|---|---|
| CC50 (MTT) (μM) | CC50 (XTT) | EC50 | SI (MTT) | SI (XTT) | ||
| pH1N1 | AmA | >50.00 | <2.54 nM | 5.93 nM | >8,431.70 | <0.43 |
| pH1N1 | BRQ | >50.00 | >50.00 μM | 0.78 μM | >64.10 | >64.10 |
| pH1N1 | 6-Azauridine | 42.66 | >50.00 μM | 0.52 μM | 82.04 | >96.15 |
| pH1N1 | Azaribine | 19.66 | >50.00 μM | 0.60 μM | 32.77 | >83.33 |
| pH1N1 | PF | 33.35 | >50.00 μM | 0.14 μM | 238.21 | >357.14 |
| pH1N1 | AVN-944 | 29.61 | >50.00 μM | 0.15 μM | 197.4 | >333.33 |
| pH1N1 | MMF | >50.00 | >50.00 μM | 1.23 μM | >40.65 | >40.65 |
| pH1N1 | MPA | >50.00 | >50.00 μM | 2.04 μM | >24.51 | >24.51 |
| pH1N1 | Ribavirin | >50.00 | >50.00 μM | 8.06 μM | >6.20 | >6.20 |
| H3N2 | AmA | >50.00 | <2.54 nM | 1.08 nM | >46,296.30 | <2.35 |
| H3N2 | BRQ | >50.00 | >50.00 μM | 0.62 μM | >80.65 | >80.65 |
| H3N2 | 6-Azauridine | 42.66 | >50.00 μM | 0.41 μM | 104.05 | >121.95 |
| H3N2 | Azaribine | 19.66 | >50.00 μM | 0.77 μM | 25.53 | >64.94 |
| H3N2 | PF | 33.35 | >50.00 μM | 0.28 μM | 119.11 | >178.57 |
| H3N2 | AVN-944 | 29.61 | >50.00 μM | 0.99 μM | 29.91 | >50.51 |
| H3N2 | MMF | >50.00 | >50.00 μM | 0.36 μM | 138.89 | 138.89 |
| H3N2 | MPA | >50.00 | >50.00 μM | 0.83 μM | 60.24 | 60.24 |
| H3N2 | Ribavirin | >50.00 | >50.00 μM | 4.89 μM | >10.22 | >10.22 |
| IBV | AmA | >50.00 | <2.54 nM | 5.81 nM | >8,605.85 | <0.44 |
| IBV | BRQ | >50.00 | >50.00 μM | 0.25 μM | >200.00 | >200.00 |
| IBV | 6-Azauridine | 42.66 | >50.00 μM | 0.71 μM | 60.08 | >70.42 |
| IBV | Azaribine | 19.66 | >50.00 μM | 0.80 μM | 24.57 | >62.50 |
| IBV | PF | 33.35 | >50.00 μM | 63.51 nM | 525.11 | >787.28 |
| IBV | AVN-944 | 29.61 | >50.00 μM | 0.11 μM | 269.18 | >454.54 |
| IBV | MMF | >50.00 | >50.00 μM | 0.10 μM | >500.00 | >500.00 |
| IBV | MPA | >50.00 | >50.00 μM | 0.79 μM | >63.29 | >63.29 |
| IBV | Ribavirin | >50.00 | >50.00 μM | 0.11 μM | >454.55 | >454.55 |
a
pH1N1, A/California/04/09 H1N1; H3N2, A/Wyoming/03/03 H3N2; IBV, B/Brisbane/60/08.
b
CC50, median 50% cytotoxicity concentration; EC50, median 50% effective concentration; SI, selective index (CC50/EC50).