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. 2020 Mar 17;94(7):e00127-20. doi: 10.1128/JVI.00127-20

FIG 3.

FIG 3

Sequence comparison of 2019-nCoV and SARS-CoV. (A) Sequence alignment of SARS-CoV and 2019-nCoV RBDs. RBM residues are in magenta. The five critical residues in Fig. 1B are in blue. ACE2-contacting residues are shaded. Asterisks indicate positions that have a single, fully conserved residue. Colons indicate positions that have strongly conserved residues. Periods indicate positions that have weakly conserved residues. (B) Sequence similarities of SARS-CoV and 2019-nCoV in the spike protein, RBD, and RBM, respectively. (C) Sequence similarities of MERS-CoV and HKU4 virus in the spike protein, RBD, and RBM, respectively. GenBank accession numbers are JX869059.2 for human MERS-CoV spike and NC_009019.1 for bat HKU4-CoV spike.