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. 2020 Mar 17;94(7):e00127-20. doi: 10.1128/JVI.00127-20

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Copyright © 2020 American Society for Microbiology.

This article is made available via the PMC Open Access Subset for unrestricted noncommercial re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.

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FIG 4 — Structural analysis of animal ACE2 recognition by 2019-nCoV and SARS-CoV. (A) Critical changes in virus-contacting residues of ACE2 from different host species. GenBank accession numbers for ACE2 are as follows: NM_001371415.1 (human), AAX63775.1 (civet), KC881004.1 (bat), NP_001123985.1 (mouse), AY881244 (rat), NP_001116542.1 (pig), AB208708 (ferret), NM_001039456 (cat), Q5RFN1 (orangutan), and AY996037 (monkey). (B) Experimentally determined structure of the interface between a designed SARS-CoV RBD (optimized for civet ACE2 recognition) and civet ACE2. PDB ID is 3SCK. (C) Modeled structure of the interface between 2019-nCoV RBD and civet ACE2. Here, mutations were introduced to the RBD region in panel B based on sequence differences between SARS-CoV and 2019-nCoV.