TABLE 4.
Recommendation of the most potent T cell epitopes classified by HLA (super)type
| HLA typeb | Reported epitope |
Novel/validated epitopea |
||||
|---|---|---|---|---|---|---|
| Designation | Sequence | HLA (super)type(s) | Designation | Sequence | HLA (super)type | |
| A*01 | p166-173 | ASFCGSPY | A*01:01, A*29:02, A*30:02 | p549-557 | YMDDVVLGA | A*01:01 |
| A*02 | p147-156 | YLHTLWKAGI | A*02 | p368-376 | RVTGGVFLV | A*02:01 |
| p374-383 | FLVDKNPHNT | A*02:03 | p407-415 | FAVPNLQSL | A*02:01 | |
| p418-426 | LLSSNLSWL | A*02:01 | p693-701 | GLCQVFADA | A*02:01 | |
| p422-430 | NLSWLSLDV | A*02 | x15-23 | VLCLRPVGA | A*02:01 | |
| p500-508 | KLHLYSHPI | A*02:03 | ||||
| p502-510 | HLYSHPIIL | A*02 | ||||
| p549-557 | YMDDVVLGA | A*02:01 | ||||
| p653-661 | ALMPLYACI | A*02:01, A*02:02, A*02:03, A*02:04, A*02:06 | ||||
| x52-60 | HLSLRGLPV | A*02:01 | ||||
| x91-100 | KVLHKRTLGL | A*02:01 | ||||
| x92-100 | VLHKRTLGL | A*02:01 | ||||
| x99-108 | GLSAMSTTDL | A*02 | ||||
| x102-110 | AMSTTDLEA | A*02:01 | ||||
| x133-141 | VLGGCRHKL | A*02:01 | ||||
| A*03 | p47-55 | NVSIPWTHK | A*03, A*11, A*68:01 | p275-283 | CLHQSAVRK | A*03:01 |
| p55-63 | KVGNFTGLY | A*03, A*11 | p55-63 | KVGNFTGLY | A*03:01 | |
| p149-159 | HTLWKAGILYK | A*03, A*11, A*31:01, A*33:01, A*68:01 | x70-78 | ALRFTSARR | A*03:01 | |
| p150-158 | TLWKAGILY | A*03, A*11 | ||||
| p150-159 | TLWKAGILYK | A*03, A*11 | ||||
| p369-378 | VTGGVFLVDK | A*03, A*11 | ||||
| p388-397 | LVVDFSQFSR | A*11, A*33:01, A*68:01 | ||||
| p389-397 | VVDFSQFSR | A*33, A*11, A*68:01 | ||||
| p549-558 | YMDDVVLGAK | A*03 | ||||
| A*11 | p47-55 | NVSIPWTHK | A*03, A*11, A*68:01 | p164-173 | RSASFCGSPY | A*11:01 |
| p55-63 | KVGNFTGLY | A*03, A*11 | p369-378 | VTGGVFLVDK | A*11:01 | |
| p149-159 | HTLWKAGILYK | A*03, A*11, A*31:01, A*33:01, A*68:01 | x104-113 | STTDLEAYFK | A*11:01 | |
| p150-158 | TLWKAGILY | A*03, A*11 | ||||
| p150-159 | TLWKAGILYK | A*03, A*11 | ||||
| p368-378 | RVTGGVFLVDK | A*11 | ||||
| p369-378 | VTGGVFLVDK | A*03, A*11 | ||||
| p388-397 | LVVDFSQFSR | A*11, A*33:01, A*68:01 | ||||
| p389-397 | VVDFSQFSR | A*33, A*11, A*68:01 | ||||
| p746-755 | GTDNSVVLSR | A*11 | ||||
| x135-143 | GGCRHKLVC | A*11:01 | ||||
| A*24 | p756-764 | KYTSFPWLL | A*24:02 | p166-175 | ASFCGSPYSW | A*24:02 |
| p167-175 | SFCGSPYSW | A*24:02 | ||||
| p403-412 | SWPKFAVPNL | A*24:02 | ||||
| p649-658 | CGYPALMPLY | A*24:02 | ||||
| p650-658 | GYPALMPLY | A*24:02 | ||||
| p697-706 | VFADATPTGW | A*24:02 | ||||
| p755-764 | RKYTSFPWLL | A*24:02 | ||||
| p756-764 | KYTSFPWLL | A*24:02 | ||||
| p756-765 | KYTSFPWLLG | A*24:02 | ||||
| x62-73 | AFSSAGPCALRF | A*24:02 | ||||
| x110-120 | AYFKDCVFKDW | A*24:02 | ||||
| B*07 | p365-374 | TPARVTGGVF | B*35, B*51 | p365-373 | TPARVTGGV | B*07:02 |
| p440-448 | HPAAMPHLL | B*07:02 | p365-374 | TPARVTGGVF | B*07:02 | |
| p651-659 | YPALMPLYA | B*07:02, B*35:01, B*51, B*54:01 | p404-412 | WPKFAVPNL | B*07:02 | |
| p789-797 | DPSRGRLGL | B*07:02 | p515-523 | IPMGVGLSP | B*07:02 | |
| p723-731 | LPIHTAELL | B*07:02 | ||||
| x58-66 | LPVCAFSSA | B*07:02 | ||||
| B*08 | p500-508 | KLHLYSHPI | B*08:01 | |||
| p509-517 | ILGFRKIPM | B*08:01 | ||||
| B*58 | p166-175 | ASFCGSPYSW | B*58:01 | |||
a
Validated for the tested HLA type (underlining)/tested for an HLA type other than the one previously reported (italics).
b
Boldface HLA type indicates groups of epitopes with preference for this particular HLA type in the corresponding gray/white area.