TABLE 1.
Binding affinity of two GMP lots of gp120 proteins
| GMP gp120 protein and lot |
Kd (M) |
||||||
|---|---|---|---|---|---|---|---|
| MAb VRC01 (CD4bs) | MAb 2G12 (glycan) | MAb PGT128 (glycan) | MAb 2158 (V2) | MAb R16 (V3) | MAb R53 (C4) | IgG-CD4 (CD4bs) | |
| Clade A, lot 1 | 6.04E−09 | 3.11E−10 | 7.68E−10 | 6.85E−09 | 5.59E−10 | 6.76E−08 | 5.48E−09 |
| Clade A, lot 2 | 5.96E−09 | 1.80E−10 | 7.62E−10 | 6.46E−09 | 2.81E−10 | 2.76E−08 | 3.62E−09 |
| Clade B, lot 1 | 3.11E−08 | <1.0E−12 | 2.46E−09 | 4.55E−09 | 3.49E−10 | 1.16E−08 | 7.44E−09 |
| Clade B, lot 2 | 2.83E−08 | <1.0E−12 | 2.10E−09 | 3.26E−09 | 4.56E−10 | 1.32E−08 | 4.87E−09 |
| Clade C, lot 1 | 4.53E−08 | 5.54E−09 | 3.25E−08 | 2.61E−08 | 3.80E−10 | 5.63E−09 | 1.57E−07 |
| Clade C, lot 2 | 5.21E−08 | 2.24E−09 | 2.03E−08 | 3.31E−08 | 4.27E−10 | 4.98E−08 | 1.15E−07 |
| Clade AE, lot 1 | 5.25E−08 | 8.02E−09 | 3.71E−08 | 3.05E−08 | 5.87E−10 | 8.89E−09 | 2.46E−08 |
| Clade AE, lot 2 | 3.53E−08 | 8.62E−09 | 2.62E−08 | 3.32E−08 | 3.22E−10 | 5.63E−09 | 1.84E−08 |