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Binding affinities of compounds for various targets. (A) RNA and DNA sequences used in MST experiments. (B) Affinities of 1, 2, and 3 for Cy5-labeled (CCUG)12, Cy5-labeled RNA base paired control, or a Cy5-labeled AT-rich DNA hairpin, as determined by MST. (C) Studying the DNA cleaving activity of 2, 3, and bleomycin A5 in vitro. Error bars represent SD, n = 5.
