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. Author manuscript; available in PMC: 2020 Apr 15.
Published in final edited form as: Acc Chem Res. 2019 Sep 5;52(10):2841–2848. doi: 10.1021/acs.accounts.9b00386

Figure 7.

Figure 7.

Chemiluminescent ABS probes for FA. (a) Reaction scheme for the detection of FA by chemiluminescent probes CFAP540 and CFAP700. (b) Chemiluminescence imaging of mice injected with 100 μM CFAP700 in the presence of FA or tetrahydrofolate (THF) at the indicated concentrations compared with vehicle. Bar graphs present total photon fluxes integrated from 0 to 25 min postinjection (mean ± SEM, n = 3–4). Statistical analyses were performed with a two-tailed Student’s t test (*, P ≤ 0.05; **, P ≤ 0.01). Adapted with permission from ref 50. Copyright 2018 Wiley-VCH.