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. 2020 Mar 9;16(3):e1008651. doi: 10.1371/journal.pgen.1008651

Fig 2. Transmission electron microscopy of the control and affected lungs.

Fig 2

(A) Age-matched control. An intact AECII cell showing normal LBs with tightly packed lamellae (arrowheads). In the alveolar airspace, surfactant is still in the form of multiple concentric lamellar whorls (arrows) (scale bar 2 μm). (B) Age-matched control. Multiple cytoplasmic LBs showing intact limiting membranes with intraorganellar, parallel packed phospholipid lamellae (arrowheads) (scale bar 1 μm). (C) Affected puppy. AECII cell hyperplasia in the alveolar wall with three severely altered AECII cells (asterisks) in apposition (scale bar 2 μm). (D) Affected puppy. A high power view of the cytoplasm of an AECII cell showing structures compatible with CBs (black arrowheads) without any mature LBs. The limiting membrane is occasionally disrupted (white arrowheads) (scale bar 1 μm).