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. 2020 Mar 9;16(3):e1008552. doi: 10.1371/journal.pgen.1008552

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© 2020 Wang et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 1 — (A) MSMC2 analyses patterns of mutations between pairs of haplotypes to estimate local coalescence times along the genome. (B) MSMC-IM fits an isolation-migration model to the pairwise coalescence rate estimates, with time-dependent population sizes and migration rate. (C) As a result, we obtain the migration rate over time, m(t), and the cumulative migration probability, M(t), which denotes the probability for lineages to have merged by the time t and which we use to estimate fractions of ancestry contributed by lineages diverged deeper than time t.