Skip to main content
. Author manuscript; available in PMC: 2020 Mar 19.
Published in final edited form as: Cell Rep. 2020 Feb 25;30(8):2655–2671.e7. doi: 10.1016/j.celrep.2020.02.003

Figure 1. SPR Analysis of trans Binding Interactions in the δ-protocadherin Family.

Figure 1.

(A) Phylogenetic tree of human δ-protocadherins from aligned full-length amino acid sequences. Atypical members italicized. Scale indicates protein distance.

(B) SPR binding profiles of δ-protocadherin analytes (columns) over surfaces coated with the same set of proteins (rows).

Analyte concentrations of 27, 9, and 3 μM are plotted on each panel. Responses are normalized for molecular weight and scaled for each surface, permitting comparison across rows only. Homophilic combinations are highlighted in green; heterophilic interactions within δ1- and δ2-subfamilies are boxed in teal and red. See Figure S1.