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. Author manuscript; available in PMC: 2020 Mar 19.
Published in final edited form as: Cell Rep. 2020 Feb 25;30(8):2655–2671.e7. doi: 10.1016/j.celrep.2020.02.003

Figure 4. SPR Analysis of Targeted trans Interface Mutations.

Figure 4.

(A) Homophilic binding of wild-type and trans interface mutant δ1 EC1–EC4 fragments of pcdh-1, −7, and −9 over their respective wild-type surfaces.

(B) Effects of trans interface mutations in pcdh1 and −7 on heterophilic binding to pcdh-9 (left) and −11 (right).

(C) Homophilic binding of wild-type and trans interface mutants of δ2-pcdh-10, −12, −17, −18, and −19 over wild-type surfaces. Three analyte concentrations (27, 9, and 3 μM) are plotted and responses are scaled independently for each surface.