Figure 1. (A) Schematic of the α-hemolysin pore embedded in a lipid membrane. Unfolded and simple α-helical or β-sheet forming peptides can readily translocate. (B) Typical current trace of Aβ₁₋₄₀ recorded for 10 sec. The open pore current is 100 pA and each spike represents an event where a single peptide interacts with the pore. Typically for a peptide, large spikes are due to translocations and short spikes are bumping events.