Table 2. Summary of the PrPd cell distribution according to strain and host.
Strain | Host | ITNR | ITGL | GLAS | NRPL | EPEN | NVPL | VSPL |
---|---|---|---|---|---|---|---|---|
ME7 | Suff AA | 23 ± 2 | 10 ± 2 | 19 ± 0 | 44 ± 5 | 1 ± 2 | 0.3 ± 0 | 2 ± 2 |
Chev VV | 14 ± 9 | 23 ± 5 | 29 ± 8 | 31 ± 18 | 0.0 | 0.0 | 2 ± 2 | |
Chev AA | 23 ± 16 | 18 ± 4 | 23 ± 2 | 35 ± 21 | 0.0 | 0.0 | 0.0 | |
79A | Suff AA | 12 | 32 | 21 | 35 | 3 | 0.0 | 0.0 |
Chev VV | 4 ± 3 | 37 ± 10 | 35 ± 13 | 25 ± 0 | 0.0 | 0.0 | 0.0 | |
Chev AA | 18 ± 15 | 23 ± 20 | 21 ± 23 | 37 ± 13 | 0.0 | 0.0 | 0.0 | |
22A | Suff AA | 22 | 23 | 23 | 29 | 2 | 0.0 | 0.0 |
ChevVV | 19 ± 6 | 26 ± 8 | 32 ± 1 | 10 ± 5 | 13 ± 19 | 0.0 | 0.0 | |
Chev AA | 5 ± 5 | 4 ± 2 | 34 ± 12 | 44 ± 15 | 4 ± 6 | 11 ± 15 | 0.0 | |
87A | Suff AA | 44 | 29 | 1 | 26 | 0.0 | 0.0 | 0.0 |
Chev VV | 45 | 36 | 0.5 | 18 | 0.0 | 0.0 | 0.0 | |
Chev AA | 52 | 37 | 1 | 10 | 0.0 | 0.0 | 0.0 |
The scores shown are average short PrPd profiles grouped according to the host and to the strain but not the route. The intraneuronal (ITNR) score (in percentage) is the amount of PrPd found within the perikarya of neurons relative to that found elsewhere. The intraglial (ITGL) type includes the intra-astrocytic and intra-microglial. The glia-associated PrPd (GLAS) includes the stellate, subpial, subependymal, perivascular and perivacuolar PrPd types. The neuropil-associated PrPd includes the particulate, linear and perineuronal. Plaque-like PrPd was scored as associated with plaques (vascular plaques [VSPL]) or not (non-vascular plaques [NVPL]). The host was either Suffolk (Suff) or Cheviot (Chev) sheep and of ARQ/ARQ (AA) or VRQ/VRQ (VV) Prnp genotype