Figure 4. Diagnostic algorithm for early prediction of resistance to tyrosine kinase inhibitors by RT-PCR plasma monitoring of EGFR mutations in NSCLC.

Simulated examples of sEGFRma plasma curves in good and poor responders are reported (see text for details). sEGFRma, sensitizing EGFR mutant allele; RT-PCR, Real-Time-Polymerase Chain Reaction.