Skip to main content
. Author manuscript; available in PMC: 2020 Mar 19.
Published in final edited form as: Cell Rep. 2020 Mar 3;30(9):2900–2908.e4. doi: 10.1016/j.celrep.2020.02.039

Figure 2. Summary of Gene-Level Association Results.

Figure 2.

(A) Gene-level association testing identified 23 unique candidate genes. Four candidate genes contained published GWAS SNPs related to cancer traits; five candidate genes contained published GWAS SNPs related to immunity or autoimmune traits. Out of the genes with no previously known associations, the Gene Ontology (GO) term with the most members is shown. Suggestive and candidate genes annotated as casually implicated in cancer by the Cancer Gene Census are also shown. Genes are colored according to the phenotype category for which they are most significant. Genes associated with multiple phenotypes, including suggestive associations, are denoted with a colored asterisk. Genes with only suggestive associations are underlined. See also Table S2. (B) Manhattan plot for gene-level association analysis for the CD8+ T cell phenotype. Each point represents a gene. Positions along the chromosomes are on the x axis, and −log10-transformed p values are on the y axis. The solid red line indicates gene-level significance (p < 2.8 × 10−6), and the dashed red line indicates suggestive significance (p < 2.9 × 10−5).