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. Author manuscript; available in PMC: 2020 Mar 19.
Published in final edited form as: Cell Rep. 2020 Mar 3;30(9):2900–2908.e4. doi: 10.1016/j.celrep.2020.02.039

Figure 3. Altered Subnetworks in Leukocyte Fraction Phenotype.

Figure 3.

Two statistically significant (p < 0.05) altered subnetworks associated with the leukocyte fraction phenotype in the ReactomeFI 2016 interaction network. Each rectangle represents a gene and is colored according to the gene-level p value. Two genes are connected if their protein products interact in the ReactomeFI 2016 interaction network. Underlined genes are suggestive genes from gene-level analysis.

(A) Two suggestive genes, ATR and HSPA2, are part of a larger subnetwork involved in DNA repair. Genes involved in DNA repair or metabolism are indicated by * and §, respectively.

(B) A subnetwork containing important members of the nucleotide excision repair and transcription elongation pathway, indicated by # and †, respectively.