Table 3:
Multivariable GEE Significance Tests
| Prenatal Anxiety1 | Prenatal Depression1 | |||||
|---|---|---|---|---|---|---|
| NNNS Summary Score and Predictors | B | SE | Adjusted Means Anxiety ; No Anxiety | B | SE | Adjusted Means Depression; No Depression |
| Attention (625) | −0.43* | 0.18 | 4.88 ; 5.31 | −0.45 | 0.29 | 4.86 ; 5.31 |
| Neonatal Medical Complications | −0.36** | 0.07 | −0.36** | 0.07 | ||
| PMA at Exam | 0.31** | 0.08 | 0.31** | 0.08 | ||
| Handling (652) | −0.02 | 0.04 | 0.39 ; 0.41 | −0.06 | 0.04 | 0.35 ; 0.41 |
| PMA at Exam | −0.03* | 0.01 | −0.03* | 0.01 | ||
| Quality of Movement (657) | −0.02 | 0.12 | 4.57 ; 4.59 | −0.18 | 0.13 | 4.41 ; 4.60 |
| Socioenvironmental Risk | −0.08** | 0.03 | −0.07** | 0.03 | ||
| Self-Regulation (654) | −0.10 | 0.13 | 5.53 ; 5.62 | −0.29 | 0.16 | 5.34 ; 5.63 |
| Socioenvironmental Risk | −0.07* | 0.03 | −0.07* | 0.03 | ||
| Excitability (657) | −0.06 | 0.35 | 2.44 ; 2.50 | 0.34 | 0.43 | 2.81 ; 2.48 |
| PMA at Exam | 0.25* | 0.11 | 0.26* | 0.11 | ||
| Lethargy (657) | 0.50 | 0.28 | 5.01 ; 4.51 | 1.01* | 0.41 | 5.49 ; 4.49 |
| Neonatal Medical Complications | 0.36** | 0.10 | 0.35** | 0.11 | ||
| PMA at Exam | −0.30** | 0.11 | −0.30** | 0.11 | ||
| Arousal (657) | −0.04 | 0.09 | 3.71 ; 3.75 | −0.08 | 0.13 | 3.67 ; 3.75 |
| PMA at Exam | 0.08* | 0.03 | 0.08* | 0.03 | ||
| Stress-Abstinence (657) | −0.01 | 0.01 | 0.13 ; 0.14 | −0.01 | 0.01 | 0.13 ; 0.14 |
| Substance Use Index | −0.01** | 0.003 | −0.01** | 0.003 | ||
| Hypertonicity (657) | 0.14 | 0.14 | 0.50 ; 0.36 | 0.15 | 0.15 | 0.51 ; 0.36 |
| PMA at Exam | 0.11** | 0.04 | 0.11** | 0.04 | ||
| Hypotonicity (657) | -*** | - | −0.02 | 0.07 | 0.21 ; 0.23 | |
| Substance Use Index | - | - | −0.03** | 0.01 | ||
| Non-optimal Reflexes (657) | 0.19 | 0.28 | 5.55 ; 5.36 | −0.11 | 0.35 | 5.27 ; 5.38 |
| Neonatal Medical Complications | 0.33** | 0.10 | 0.33** | 0.10 | ||
| Maternal Medical Risk | 0.20* | 0.09 | 0.20* | 0.09 | ||
| Asymmetrical Reflexes (657) | 0.04 | 0.19 | 1.01 ; 0.97 | −0.08 | 0.19 | 0.90 ; 0.98 |
Notes: Significant predictors are tabled for *p<.05, **p<.01 with Bonferroni correction for multiple tests. Separate models testing anxiety and depression examined associations with all of the following: neonatal medical risk, maternal medical risk, socioenvironmental risk, and PMA at NNNS exam, after adjusting for site.
***
Model did not converge.
1
There were no significant associations between NNNS scores and prenatal use of prescribed antidepressant or anxiolytic medication.