Table 2.
Greater activation in OCD patients than controls during early eyeblink suppression
| Label | Harvard‐Oxford parcel | BA | k | x | y | z |
|---|---|---|---|---|---|---|
| Frontal/insular | ||||||
| Inferior frontal gyrus/orbital gyrus | Frontal orbital cortex (L) | 47 | 20 | −42 | 18 | −8 |
| Insula/inferior frontal gyrus | Insular cortex (L) | 13, 47 | 126 | −36 | 6 | −12 |
| Insula/claustrum | Insular cortex (L) | 42 | −32 | 12 | 0 | |
| Mid cingulate/anterior cingulate | Cingulate gyrus, anterior (L) | 24, 32 | 80 | −6 | 10 | 30 |
| Parietal | ||||||
| Paracentral lobule/precuneus/postcentral gyrus | Postcentral gyrus (R) | 4, 5 | 28 | 14 | −42 | 56 |
| Inferior parietal lobule/supramarginal gyrus/angular gyrus | Angular gyrus (L) | 40 | 246 | −50 | −56 | 26 |
| Inferior parietal lobule/supramarginal gyrus/angular gyrus | Angular gyrus (R) | 40 | 315 | 54 | −44 | 24 |
| Inferior parietal lobule/superior parietal lobule | Superior parietal lobule (L) | 7, 40 | 178 | −32 | −54 | 38 |
| Inferior parietal lobule/superior parietal lobule | Superior parietal lobule (R) | 7, 40 | 218 | 32 | −46 | 38 |
| Inferior parietal lobule/supramarginal gyrus | Supramarginal gyrus, anterior (L) | 40 | 128 | −60 | −38 | 36 |
| Inferior parietal lobule/supramarginal gyrus | Supramarginal gyrus, posterior (L) | 40 | 323 | −58 | −52 | 30 |
| Inferior parietal lobule/supramarginal gyrus/postcentral gyrus | Supramarginal gyrus, posterior (R) | 40 | 464 | 52 | −44 | 22 |
| Superior parietal lobule/middle occipital gyrus/precuneus/inferior parietal lobule/angular gyrus | Lateral occipital cortex, superior (L) | 7, 19, 39, 40 | 620 | −22 | −82 | 20 |
| Angular gyrus/superior parietal lobule/inferior parietal lobule/precuneus/middle occipital gyrus | Lateral occipital cortex, superior (R) | 7, 39, 40 | 337 | 42 | −62 | 30 |
| Mid cingulate/posterior cingulate/precuneus | Cingulate gyrus, posterior (B) | 23, 24, 31 | 555 | −2 | −38 | 24 |
| Posterior cingulate/precuneus/lingual gyrus | Cingulate gyrus, posterior (B) | 29 | 28 | 22 | −48 | 2 |
| Precuneus/cuneus/mid cingulate/posterior cingulate/superior parietal lobule/paracentral lobule | Precuneus cortex (B) | 5, 7, 20, 31 | 1,702 | 10 | −54 | 4 |
| Calcarine/posterior cingulate | Precuneus cortex (L) | 30 | 20 | −20 | −62 | 4 |
| Occipital | ||||||
| Calcarine/cuneus/posterior cingulate/lingual gyrus | Intracalcarine cortex (L) | 17, 18, 23, 30 | 173 | −16 | −68 | 2 |
| Calcarine/cuneus/posterior cingulate/lingual gyrus | Intracalcarine cortex (R) | 30 | 72 | 22 | −64 | 2 |
| Cuneus/calcarine/lingual gyrus | Intracalcarine cortex (R) | 30 | 53 | 6 | −84 | 0 |
| Calcarine/posterior cingulate/cuneus | Supracalcarine cortex (R) | 31 | 41 | 22 | −64 | 12 |
| Cuneus | Supracalcarine cortex (R) | 17, 18 | 21 | 2 | −86 | 4 |
| Lingual gyrus/cuneus/parahippocampal gyrus/precuneus | Lingual gyrus (L) | 18, 19, 30 | 120 | −16 | −48 | −4 |
| Lingual gyrus/cerebellum | Lingual gyrus (L) | 67 | −18 | −66 | −14 | |
| Lingual gyrus/calcarine/cuneus | Lingual gyrus (R) | 18, 30 | 119 | 10 | −88 | −12 |
| Lingual gyrus/calcarine/parahippocampal gyrus | Lingual gyrus (R) | 18, 19, 30 | 56 | 20 | −76 | −4 |
| Cuneus/precuneus/superior occipital gyrus | Cuneal cortex (L) | 7, 18, 19, 31 | 198 | −14 | −74 | 18 |
| Cuneus/precuneus | Cuneal cortex (R) | 7, 18, 19, 31 | 389 | 2 | −88 | 14 |
| Middle occipital gyrus/inferior occipital gyrus/inferior temporal gyrus | Lateral occipital cortex, inferior (L) | 19, 37, 39 | 316 | −42 | −70 | −12 |
| Middle occipital gyrus | Lateral occipital cortex, inferior (R) | 19 | 31 | 36 | −82 | 6 |
| Middle occipital gyrus/middle temporal gyrus | Lateral occipital cortex, superior (L) | 19 | 83 | −34 | −88 | 6 |
| Middle occipital gyrus/ middle temporal gyrus | Lateral occipital cortex, superior (R) | 19 | 85 | 38 | −82 | 10 |
| Middle occipital gyrus | Lateral occipital cortex, superior (R) | 19 | 53 | 28 | −72 | 22 |
| Cuneus/middle occipital gyrus/superior occipital gyrus/calcarine | Occipital pole (L) | 17, 18, 19 | 265 | −4 | −92 | −2 |
| Cuneus/calcarine | Occipital pole (R) | 18, 19 | 29 | 4 | −90 | 4 |
| Subcortical | ||||||
| Caudate head | Caudate (L) | 44 | −14 | 16 | −4 | |
| Putamen (lentiform nucleus) | Putamen (L) | 123 | −26 | 4 | −10 | |
| Putamen (lentiform nucleus) | Putamen (L) | 29 | −32 | −16 | −8 | |
| Hippocampus/thalamus | Thalamus (L) | 27 | 31 | −20 | −34 | −4 |
| Hippocampus/parahippocampal gyrus | Hippocampus (L) | 27, 30 | 73 | −24 | −30 | −12 |
| Cerebellum (culmen/declive) | Cerebellum crus 1 (R) | 181 | 42 | −52 | −36 | |
| Cerebellum (culmen/declive) | Cerebellum 4_5 (L) | 49 | −10 | −56 | −22 | |
| Cerebellum (culmen/declive) | Cerebellum 6 (L) | 217 | −14 | −64 | −28 | |
| Cerebellum (culmen/declive) | Cerebellum 6 (R) | 345 | 30 | −56 | −34 | |
| Cerebellum (declive) | Vermis 6 (B) | 51 | −4 | −62 | −24 | |
| Cerebellum (declive) | Vermis 7 (B) | 27 | 6 | −66 | −26 | |
Note: Labels are derived from the AAL and Talairach Daemon databases as provided through xjview (v. 9.6, http://www.alivelearn.net/xjview). Harvard‐Oxford Atlas parcels are provided through the “conn” tool (Whitfield‐Gabrieli & Nieto‐Castanon, 2012). Within a given cluster, labels are listed in descending order based on the proportion of voxels within the cluster assigned to that label. Some clusters span across two different lobes; for these clusters, lobe assignment is based on the lobe with the greatest proportion of voxels in that cluster. Coordinates are in MNI space. Only clusters with 20 or more contiguous voxels are listed. Parcels represent subdivisions from clusters corrected for a whole‐brain FWE rate of p < .05 using permutation testing.
Abbreviations: AAL, Automated Anatomical Labeling; B, bilateral; BA, Brodmann's areas; FWE, family wise error; k, cluster extent; L, left; OCD, obsessive–compulsive disorder; R, right.