Table 2.

The relationships between serum lipid parameters and cognitive impairment with binary logistic regression in the total samples.

		B	SE	Wald’s χ2	OR	95% CI	p-value
Model 1
	High TC	−0.195	0.222	0.771	0.823	0.533–1.271	0.380
	High TG	−0.167	0.239	0.487	0.846	0.529–1.353	0.485
	High LDL-c	−0.062	0.312	0.039	0.940	0.511–1.732	0.843
	Low HDL-c	0.595	0.655	0.824	1.813	0.502–6.544	0.364
Model 2
	High TC	−0.161	0.226	0.506	0.851	0.546–1.326	0.477
	High TG	−0.144	0.250	0.333	0.866	0.531–1.413	0.564
	High LDL-c	−0.061	0.319	0.036	0.941	0.504–1.757	0.849
	Low HDL-c	0.718	0.655	1.203	2.051	0.568–7.404	0.273
Model 3
	High TC	−0.077	0.248	0.096	0.926	0.569–1.507	0.757
	High TC by APOE ε4 status	−0.462	0.568	0.662	0.630	0.207–1.918	0.416
	High TG	−0.174	0.279	0.390	0.840	0.486–1.452	0.532
	High TG by APOE ε4 status	0.146	0.592	0.061	1.157	0.363–3.692	0.805
	High LDL-c	−0.180	0.382	0.222	0.835	0.395–1.766	0.637
	High LDL-c by APOE ε4 status	0.435	0.704	0.381	1.544	0.389–6.136	0.537
	Low HDL-c	−0.354	1.061	0.111	0.702	0.088–5.614	0.739
	Low HDL-c by APOE ε4 status	3.000	1.452	4.269	20.094	1.167–346.056	0.039

Binary logistic regression model was used for data analysis, df = 1. APOE ε4 carrier status: dummy coded with ε4 carriers = 1, non-carriers = 0. Model 1 was adjusted for age, gender, and education years. Model 2 was adjusted for age, gender, education years, smoking, drinking, intensity of physical activity, body mass index, log-transformed fasting blood glucose, mean arterial pressure, pulse rate, heart disease, and APOE ε4 carrier status. Model 3 was adjusted for the covariates included in model 2 as well as the interaction terms of APOE ε4 carrier status by serum lipids. TC, total cholesterol; LDL-c, low-density lipoprotein; HDL-c, high-density lipoprotein; TG, triglycerides; APOE, apolipoprotein E.