Table 3.
Difference of the cognitive impairment, serum lipid levels, and other covariates between APOE ε4 carriers and non-carriers.
| APOE ε4 non-carriers (n = 1,084) | APOE ε4 carriers (n = 189) | df | p-value | |
|---|---|---|---|---|
| Age, years (mean ± SD) | 57.0 ± 9.8 | 57.5 ± 9.3 | 1,271 | 0.501 |
| Gender, female (%) | 642 (59.2) | 113 (59.8) | 1 | 0.884 |
| Education, years (mean ± SD) | 6.5 ± 3.4 | 6.2 ± 3.5 | 1,271 | 0.228 |
| Drinking, n (%) | 133 (12.3) | 20 (10.6) | 1 | 0.510 |
| Smoking, n (%) | 343 (31.6) | 57 (30.2) | 1 | 0.685 |
| Lack of activity, n (%) | 217 (20.0) | 35 (18.5) | 1 | 0.633 |
| Cardiovascular disease, n (%) | 103 (9.5) | 11 (5.8) | 1 | 0.102 |
| Hypertension, n (%) | 410 (37.8) | 69 (36.5) | 1 | 0.731 |
| Diabetes mellitus, n (%) | 116 (10.7) | 26 (13.8) | 1 | 0.218 |
| MAP, mmHg (mean ± SD) | 95.7 ± 11.8 | 95.6 ± 11.3 | 1,271 | 0.860 |
| Pulse rate (mean ± SD) | 74 ± 10 | 74 ± 9 | 1,271 | 0.771 |
| FBG, mmol/L, median (quartile) | 5.33 (5.01, 5.80) | 5.36 (5.04, 5.88) | — | 0.543 |
| BMI, kg/m2 (mean ± SD) | 25.07 ± 3.15 | 25.26 ± 3.47 | 1,271 | 0.437 |
| Cognitive impairment, n (%) | 80 (7.4) | 19 (10.1) | 1 | 0.205 |
| Dyslipidemia, n (%) | 622 (57.4) | 132 (69.8) | 1 | 0.001 |
| TC, mmol/L (mean ± SD) | 5.15 ± 0.99 | 5.36 ± 0.94 | 1,271 | 0.008 |
| TG, mmol/L, median (quartile) | 1.29 (0.96, 1.80) | 1.48 (1.09, 2.15) | — | <0.001 |
| LDL-c, mmol/L (mean ± SD) | 2.61 ± 0.66 | 2.82 ± 0.62 | 1,271 | <0.001 |
| HDL-c, mmol/L (mean ± SD) | 1.60 ± 0.34 | 1.53 ± 0.32 | 1,271 | 0.007 |
Unpaired Student’s t-test and mean ± SD were used to compare the difference of the approximately normally distributed continuous variables between APOE ε4 carriers and non-carriers. Mann-Whitney U test and median (quartile) were used for the skew distributional data. χ2 and percentage were used for categorical variables. SD, standard deviation; MAP, mean arterial pressure; FBG, fasting blood glucose; BMI, body mass index; TC, total cholesterol; LDL-c, low-density lipoprotein; HDL-c, high-density lipoprotein; TG, triglycerides; APOE, apolipoprotein E.