Table 4.

The relationships between serum lipid parameters and cognitive impairment with binary logistic regression in the subgroups according APOEε4 status.

Participants		B	SE	Wald’s χ2	OR	95% CI	p-value
APOE ε4 carriers	Model 4
	High TC	−0.716	0.545	1.724	0.489	0.168–1.423	0.189
	High TG	0.098	0.556	0.031	1.103	0.371–3.284	0.860
	High LDL-c	0.166	0.618	0.072	1.181	0.352–3.965	0.788
	Low HDL-c	3.172	1.203	6.957	23.847	2.259–251.772	0.008
	Model 5
	High TC	−0.946	0.594	2.540	0.388	0.121–1.243	0.111
	High TG	−0.238	0.615	0.150	0.788	0.236–2.628	0.698
	High LDL-c	0.060	0.665	0.008	1.062	0.288–3.914	0.928
	Low HDL-c	4.100	1.432	8.200	60.335	3.646–998.364	0.004
APOE ε4 non-carriers	Model 6
	High TC	−0.103	0.245	0.176	0.902	0.558–1.458	0.675
	High TG	−0.247	0.270	0.840	0.781	0.460–1.325	0.359
	High LDL-c	−0.219	0.376	0.339	0.803	0.384–1.680	0.561
	Low HDL-c	−0.453	1.057	0.184	0.636	0.080–5.043	0.668
	Model 7
	High TC	−0.052	0.250	0.043	0.950	0.582–1.549	0.836
	High TG	−0.176	0.283	0.385	0.839	0.482–1.461	0.535
	High LDL-c	−0.166	0.383	0.187	0.847	0.400–1.795	0.665
	Low HDL-c	−0.254	1.062	0.057	0.776	0.097–6.221	0.811

Binary logistic regression model was used for data analysis, df = 1. Models 4 and 5 were analyzed in APOE ε4 carriers. Models 6 and 7 were analyzed in APOE ε4 non-carriers. APOE ε4 carrier status: dummy coded with ε4 carriers = 1, non-carriers = 0. Models 4 and 6 were adjusted for age, gender, and education years. Models 5 and 7 were adjusted for age, gender, education years, smoking, drinking, intensity of physical activity, body mass index, log-transformed fasting blood glucose, mean arterial pressure, pulse rate, and heart disease. TC, total cholesterol; LDL-c, low-density lipoprotein; HDL-c, high-density lipoprotein; TG, triglycerides; APOE, apolipoprotein E.