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. 2020 Mar 13;8:117. doi: 10.3389/fcell.2020.00117

Figure 2.

Figure 2

hpo does not affect the amyloid-beta 42 (Aβ42) accumulation. Panels show eye imaginal discs and pupal retinae stained with the proneural marker embryonic lethal abnormal vision (ELAV; shown in red); 6E10, an anti-Aβ42 antibody (green or gray), and the membrane-specific marker discs large (Dlg; blue). (A–C) shows confocal images of eye discs for all markers (Dlg, 6E10, ELAV), whereas the 6E10 expression alone (gray) is shown in panels (A'–C'). Eye discs (A–C) and pupal retinae (D–F) of the following genotypes were compared: (A,A',D,D') glass multiple repeat (GMR)> Aβ42, (B,B',E,E') GMR> Aβ42 + hpo, and (C,C',F,F') GMR> Aβ42 + hpoRNAi. Note that activation (GMR> Aβ42 + hpo) or downregulation (GMR> Aβ42 + hpoRNAi) of Hippo signaling in GMR> Aβ42 background does not affect the accumulation of Aβ42 plaques.