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. 2020 Mar 13;8:117. doi: 10.3389/fcell.2020.00117

Figure 3.

Figure 3

Accumulation of amyloid-beta 42 (Aβ42) activates Hippo signaling. Expression levels of Hippo pathway reporters were tested in eye discs and pupal retinae. Expression of diap1 4.3-green fluorescent protein (GFP) (green, gray) is shown for eye discs and pupal retinae from (A,A',C,C') wild-type, (B,B',D,D') glass multiple repeat (GMR)> Aβ42, respectively. diap1-4.3-GFP expression is shown in a split channel in gray in (C',D') panels. Changes in ex-lacZ (green, gray) levels is shown in eye discs and pupal retinae from (E,E',F,F') wild type, (G,G',H,H') GMR> Aβ42, respectively. ex-lacZ expression is shown in a split channel in gray in (E'–H'). (I–L) shows the expression of hid-5' GFP (green), a reporter for cell death in wild-type (I,I') eye imaginal disc and (K,K') pupal retina and GMR> Aβ42 (J,J') eye imaginal disc and the (L,L') pupal retina. Gray panels (I'–L') show hid-5' GFP expression in indicated genotypes. In (I–L), nuclei are marked by the nuclear dye TOPRO (red).