Figure 4.

Presentation of neoantigens by tumors. This drawing illustrates how mutant proteins may be processed by the proteasome and transported into the endoplasmic reticulum by transporter associated with antigen processing (TAP). Peptides typically of 8–12 residues are loaded onto class I major histocompatibility complex (MHC) proteins, migrate to the cell surface and are presented. We hypothesize that the expression of chromosomal rearrangements provides a source of neoantigens that can be presented by tumor cells for recognition by the immune system. This figure was published previously (1) and is used with permission by Mayo Clinic.