Table 1. Criteria for inference of chromothripsis [adopted from (22)].

1. Clustering of breakpoints

2. Regularity of oscillating copy-number states

3. Interspersed regions of loss and retention of heterozygosity

4. Prevalence of rearrangements affecting a specific haplotype

5. Randomness of DNA segment order and fragment joins

6. Ability to walk the derivative chromosome