Table 1. Summary of recent prevalence studies on hypertension in untreated hypercortisolism.
| Study, year | Patients, n | Etiology of hypercortisolism, n | Prevalence of HTN at baseline, n (%) |
|---|---|---|---|
| Dekkers et al., 2007 (18) | 74 | CD: 74 | 58/74 (78%) |
| Valassi et al., 2011 (5) | 481 | CD: 317 | 233/306 (76%), missing data in 11 subjects |
| Adrenal CS: 130 | 103/126 (82%), missing data in 4 subjects | ||
| Ectopic CS: 24 | 21/24 (76%) | ||
| Other CS: 10 | 6/10 (60%) | ||
| Clayton et al., 2011 (19) | 60 | CD: 60 | 22/60(37%) |
| Dekkers et al., 2013 (20) | 343 | CD: 211 | 87/343 (25%), reported for entire cohort |
| Adrenal CS: 132 | |||
| Lambert et al., 2013 (21) | 346 | CD: 346 | 248/346 (72%) |
| Debono et al., 2014 (15) | 206 | Adrenal CS: 111 | 71/111 (64%) |
| Adrenal MACS: 95 | 55/95 (58%) | ||
| Di Dalmazi et al., 2014 (6) | 69 | Adrenal MACS: 69 | 45/69 (65%) |
| Clayton et al., 2016 (22) | 320 | CD: 320 | 164/320 (51%) |
| Elhassan et al., 2019 (23) | 296 | MACS: 296 | 188/296 (64%) |
Selection criteria: publication year: 2005 or after; sample size: above 50 subjects; design: retrospective, prospective studies, or systemic reviews; outcome: hypertension prevalence data available at baseline. CS, Cushing syndrome; CD, Cushing disease; MACS, mild autonomous cortisol secretion.