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. 2020 Mar 13;11:280. doi: 10.3389/fphar.2020.00280

FIGURE 1.

FIGURE 1

Compounds that have been reported to bind to Ras. (1). ND12 is a sulindac derivative that blocks the growth of Ras-transformed cells (Karaquni et al., 2002a, b). (2). The Shokat compound was identified by using a disulfide fragment-based screening approach with GDP-bound K-Ras (G12C) (Ostrem et al., 2013). (3). SCH-53239 was designed to inhibit guanine nucleotide exchange (Taveras et al., 1997). (4). ARS-853 is a selective covalent inhibitor of K-Ras G12C that inhibits mutant K-Ras–driven signaling by binding to the GDP-bound oncoprotein and preventing activation (Patricelli et al., 2016). (5). SML-8-73-1 can bind to K-Ras (G12C) (Lim et al., 2014). (6). Kobe 0065 was selected for its ability to inhibit the binding of H-Ras–GTP to Ras–Raf-binding domains (Shima et al., 2013).