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. 2020 Mar 13;10:82. doi: 10.3389/fcimb.2020.00082

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Copyright © 2020 Dean, Milton, Cavanagh and van Hoek.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Characterization of the bfpR regulon. The categorization of the bfpR regulon by mapping the RNASeq fold-change data to KEGG Pathways, with the addition of the Francisella Pathogenicity Island (FPI). The graph illustrates the RNASeq results for Log₁₀ fold-change in expression comparing bfpR Tn-mutant (FTN_1452 Tn-mutant) and bfrR^ox mutant. The change in expression of bfpR gene in the overexpressor (blue circle) was one of the most significant with a log₁₀ fold change for bfpR of 2.06 (114 fold change, Table S3, Figure S2B). The FPI gene cluster is indicated with the blue arrow.