Table 2.
Associations of increasing extent of CSVD variables and log-transformed ICH volume, ICH expansion, IVH presence, and the Graeb Score
| CSVD variable | Log ICH volume (n = 2579) | ICH expansion (n = 1813) | IVH presence (n = 2579) | Graeb Score (n = 971) | ||||
|---|---|---|---|---|---|---|---|---|
| Adjusted ß (95% CI) | P value | Adjusted OR (95% CI) | P value | Adjusted OR (95% CI) | P value | Adjusted OR (95% CI) | P value | |
| Leukoaraiosis | ||||||||
| Grade 0 | Reference | – | Reference | – | Reference | – | Reference | – |
| Grade 1 | − 0.14 (− 0.28, − 0.003) | 0.061 | 0.90 (0.63–1.27) | 0.539 | 1.22 (0.95–1.57) | 0.123 | 0.96 (0.66–1.40) | 0.844 |
| Grade 2 | − 0.10 (–0.26, 0.06) | 0.187 | 0.89 (0.61–1.28) | 0.540 | 1.55 (1.20–2.01) | 0.001* | 1.30 (0.90–1.89) | 0.160 |
| Grade 3 | − 0.18 (− 0.36, − 0.004) | 0.056 | 0.81 (0.50–1.28) | 0.379 | 1.91 (1.40–2.61) | <0.001* | 1.28 (0.84–1.94) | 0.249 |
| Grade 4 | − 0.24 (− 0.42, − 0.06) | 0.009 | 0.53 (0.33–0.85) | 0.010 | 1.95 (1.43–2.65) | <0.001* | 1.04 (0.68–1.61) | 0.850 |
| Global atrophy | ||||||||
| Grade 0 | Reference | – | Reference | – | Reference | – | Reference | – |
| Grade 1 | − 0.30 (− 0.46, − 0.14) | <0.001* | 1.34 (0.89–2.01) | 0.156 | 0.63 (0.47–0.84) | 0.002* | 0.60 (0.40–0.89) | 0.012 |
| Grade 2 | − 0.33 (− 0.49, − 0.17) | <0.001* | 1.57 (1.08–2.29) | 0.018 | 0.53 (0.41–0.69) | <0.001* | 0.44 (0.30–0.64) | <0.001* |
| Grade 3 | − 0.40 (− 0.60, − 0.20) | <0.001* | 1.62 (0.98–2.65) | 0.058 | 0.58 (0.41–0.81) | 0.002* | 0.38 (0.23–0.63) | <0.001* |
| Grade 4 | − 0.54 (− 0.76, − 0.32) | <0.001* | 1.38 (0.81–2.34) | 0.236 | 0.37 (0.25–0.54) | <0.001* | 0.29 (0.16–0.52) | <0.001* |
All models were adjusted for age, gender, and race ethnicity. In addition, analysis for ICH volume was adjusted for history of stroke, history of alcohol use, time from symptoms to CT, ICH location, presence of IVH. Analysis for ICH expansion was adjusted for history of stroke, warfarin use, platelet count on admission, time from symptoms to CT, and ICH volume. Analysis for IVH presence was adjusted for serum glucose, ICH location, ICH volume. Analysis for the Graeb Score was adjusted for admission serum glucose
CI class interval; CSVD cerebral small vessel disease, ICH intracerebral hemorrhage, IVH intraventricular hemorrhage, OR odds ratio
*P values considered significant after applying Bonferroni correction. Full models are presented in Supplementary Tables