Table 2.
Physiologic response to high intracranial pressure after TBI (mean (sd); n = 33 unless stated otherwise)
| Variable | 0–25 mm Hg | 25–50 mm Hg | 50–150 mm Hg | p (elevated vs. base) | p (severe vs. elevated) |
|---|---|---|---|---|---|
| ICP (mm Hg) | 17.52 (3.85) | 32.80 (2.39) | 61.04 (10.79) | < 0.001 | < 0.001 |
| AMP (mm Hg) | 1.83 (1.36) | 3.10 (2.08) | 5.34 (4.26) | 0.02 | < 0.001 |
| AMP/aABP (a.u.) | 0.10 (0.06) | 0.17 (0.10) | 0.29 (0.22) | 0.02 | < 0.001 |
| CPP (mm Hg) | 73.90 (9.27) | 63.79 (10.41) | 39.27 (18.11) | < 0.001 | < 0.001 |
| MAP (mm Hg) | 91.42 (9.87) | 96.61 (9.48) | 99.82 (12.55) | 0.01 | 0.120 |
| aABP (mm Hg) | 18.87 (3.32) | 19.70 (4.21) | 19.85 (5.85) | 0.16 | 0.712 |
| HR (bpm) | 77.53 (15.35) | 79.46 (19.04) | 83.78 (20.72) | 0.50 | 0.214 |
|
PRx (a.u.) (n = 24) |
0.06 (0.26) | 0.21 (0.30) | 0.57 (0.24) | 0.01 | < 0.001 |
| RAP (a.u.) | 0.54 (0.20) | 0.59 (0.25) | 0.46 (0.27) | 0.29 | 0.005 |
| PBTO2 (mm Hg) (n = 9) | 27.27 (7.32) | 20.78 (5.43) | 12.68 (7.09) | 0.06 | 0.02 |
ICP intracranial pressure, AMP pulse amplitude of ICP, aABP amplitude of arterial blood pressure, MAP mean arterial pressure, CPP cerebral perfusion pressure, HR heart rate, PRx pressure reactivity index, RAP cerebrospinal compensatory reserve, PBTO2 brain tissue oxygenation