Table 1.
Expression of adipokine receptors on human and rodent NK cells.
| Adipokine | Receptor and alternative names | Species | Detection of receptor expression in cell lines/ tissues | Percentage of surface receptor expression level [% of NK cells] | Obesity-related changes in receptor expression level | References |
|---|---|---|---|---|---|---|
| Leptin | Leptin receptor (LEP-R) Obesity receptor (ObR) CD295 |
Human | NK-92 cells | Ø | Ø | (67, 68) |
| YT cells | Ø | Ø | (68) | |||
| Peripheral blood NK cells | Very dim–dim (0–9%) | ow/ob = nw | (69–73, 77) | |||
| Hepatic NK cells | Ø | ob = nw | (74) | |||
| Rodent (rat) | Peripheral blood NK cells | Ø | ob > nw | (75) | ||
| Splenic NK cells | Ø | ob = nw | (75, 76) | |||
| Adiponectin | Adiponectin receptor 1/2 (AdipoR1/2) Progestin and adipoQ receptor 1/2 (PAQR1/2) |
Human | NKL/NK-92/KHYG cells | Ø | Ø | (78) |
| Peripheral blood NK cells | Intermediate–bright (20–90%) | ob = nw (AdipoR1); ob < nw (AdipoR2) |
(70, 79, 80) | |||
| Rodent (murine) | Splenic NK cells | Intermediate (15–17%) | Ø | (79, 81) | ||
| Interleukin-6 | IL-6 receptor (IL-6R, IL-6Ra) CD126 |
Human | NK-92 cells | Ø | Ø | (82) |
| Peripheral blood NK cells | Dim (5%) | Ø | (83) | |||
| Splenic NK cells | Dim (6%) | Ø | (83) | |||
| Tonsil NK cells | Intermediate (15%) | Ø | (83) | |||
| Rodent (murine) | Peripheral blood NK cells | Intermediate (8–25%) | ob > nw | (84) | ||
| Hepatic NK cells | Dim (8–12%) | ob = nw | (84) | |||
| Perigonadal adipose tissue | Intermediate (5–15%) | ob > nw | (84) | |||
| Splenic NK cells | Intermediate (15–40%) | Ø | (85, 86) | |||
| Estrogens | Estrogen receptor α/β (ESR1/2) |
Human | Peripheral blood NK cells | Ø | Ø | (87) |
| Rodent (murine) |
Splenic NK cells | Bright | Ø | (88) | ||
| Uterine natural killer cells | Bright | Ø | (89) |
AdipoR, adiponectin receptor; CD, cluster of differentiation; ESR, estrogen receptor; IL-6R, interleukin-6 receptor; NK cell, natural killer cell; nw, normal weight; ob, obese; ObR, obesity receptor (leptin receptor); ow, overweight; PAQR, progestin and adipoQ receptor; Ø, no data. Alternative receptor names are presented in italics.