Table 2.
Effects of adipokine treatment on human and rodent natural killer cells.
| NK cell parameter | Leptin | Adiponectin | Interleukin-6 | Estrogen | ||||
|---|---|---|---|---|---|---|---|---|
| Human | Rodent | Human | Rodent | Human | Rodent | Human | Rodent | |
| Number | ↔ | ↑↑ (rat) ↑↑ (murine) |
Ø | ↓↓ (murine) | Ø | Ø | Ø | ↑ (murine) |
| Cytotoxicity | ↓↓↓/↑↑↑ | ↑ (rat) ↑↑↑ (murine) |
↑/↔ | ↓↓↓ (murine) | ↓↓↓↓↓/↑↑↑ | ↓ (murine) | ↓ | ↓↓↓↓↓↓↓↓ (murine) |
| Expression of activating receptors | ↓↓/↑↑/↔ | ↑ (murine) | Ø | ↓/↑ (murine) | ↑/↔ | Ø | Ø | ↓↑ (murine) |
| Expression of inhibiting receptors | Ø | Ø | Ø | Ø | ↔ | Ø | Ø | ↑ (murine) |
| Migration | Ø | Ø | Ø | Ø | Ø | ↓ (murine) | ↓ | ↓ (murine) |
| Proliferation | ↓/↑/↔↔↔ | ↑ (murine) | Ø | Ø | Ø | Ø | Ø | ↓ (murine) |
| Expression of granule components | ||||||||
| Perforin | ↓/↑↑/↔↔ | Ø | Ø | Ø | ↓↓ | Ø | Ø | Ø |
| Granzymes | ↑/↔↔ | Ø | Ø | Ø | ↓↓ | Ø | Ø | ↓ (murine) |
| Cytokine secretion | ||||||||
| IFN-γ | ↓↓/↑↑/↔ | Ø | ↓ | ↓ (murine) | ↓/↑ | Ø | Ø | ↓/↑ (murine) |
| TNF-α | Ø | Ø | Ø | Ø | Ø | Ø | Ø | ↔ (murine) |
| IL-17 | Ø | Ø | Ø | Ø | Ø | ↑ (murine) | Ø | Ø |
| Maturation | Ø | Ø | Ø | ↑ (murine) | Ø | Ø | Ø | Ø |
| Metabolic activity | ↑ | Ø | Ø | Ø | Ø | Ø | ↓ | Ø |
IFN-γ, interferon γ; NK cell, natural killer cell; TNF-α, tumor necrosis factor α; ↔, no change; ↑, increase; ↓, decrease; Ø, no data. Numbers of the arrow show the number of references.