Table 3.

Overview of animal studies investigating the effect of obesity on number, subsets, phenotype, and functional parameters of NK cells in different tissues.

Adamts3, a disintegrin-like and metallopeptidase with thrombospondin type 1 motif, 3; Anxa8, annexin A8; AT, adipose tissue; Bax, Bcl-2-associated X protein; Bcl, B-cell lymphoma; BMI, body mass index; CCR, CC chemokine receptor; CD, cluster of differentiation; Csf1r, colony stimulating factor 1 receptor; H6pd, hexose-6-phosphate dehydrogenase; Hk2, hexokinase 2; IFN-γ, interferon γ; IL, interleukin; IL-6R, interleukin-6 receptor; Il18rap, interleukin 18 receptor accessory protein; Klra1, killer lectin-like receptor subfamiliy A 1; KLRG, killer cell lectin-like receptor subfamily G; Mac-1, macrophage-1 antigen; NK cell, natural killer cell; NKG, natural killer group; nw, normal weight; Nr4a1, nuclear receptor subfamily 4 group A member 1; ob, obese; ObR, obesity receptor (leptin receptor); ow, overweight; Pde5a, phosphodiesterase 5A; Renbp, renin binding protein; Scd-1, stearoyl-CoA desaturase 1; TNF-α, tumor necrosis factor α; Vegfa, vascular endothelial growth factor A.

p, pregnant;

^#, gene expression data;

^* gene expression profile analyses by micro-array, for details see publication; ♂, male; ♀, female; ↔, no change; ↑, increase; ↓ decrease; Ø, no data/not analyzed.