Fig. 4.

Ligand interaction map of the predicted binding mode of A) 43, B) 38, C) 37, D) 24S-isomer, E) 28S-isomer, F) 29R-isomer, G) 44, H) 30R-isomer, I) 34 deprotonated, J) 29S-isomer, K) 30S-isomer, and L) 27R-isomer in the ATP-binding site of the RSK2 NTKD, where red residues are charged negative, purple residues are charged positive, green residues are hydrophobic, and blue residues are polar, magenta arrows indicate H-bonds, violet lines indicate slat bridges, and gray spheres represent areas of solvent exposure.