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. 2020 Feb 4;35:100956. doi: 10.1016/j.molmet.2020.01.020

Figure 2.

Figure 2

Melanocortin receptors are presynaptic to, and their activation depolarizes histaminergic neurons via ionotropic glutamate receptors. A) Whole-cell current clamp recording showing that MTII has no effect on a HDC neuron when administered in the presence of TTX. B) Whole-cell voltage clamp recording showing MTII-induced increase in sEPSC amplitude as assessed by Kolmogorov-Smirnov test. ∗ indicates sEPSC enlarged below. C) Normalized increase in sEPSC amplitude or frequency, based off Kolmogorov-Smirnov test, following MTII administration. Numbers of cells are in parentheses. D) Whole-cell current clamp recording showing that MTII has no effect on a HDC neuron when administered in the presence of the ionotropic glutamate receptor antagonists CNQX and AP5. Note: // denotes discontinuity in the recording where current voltage relations were performed (35 sec and 45 sec, in A and D respectively).