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. 2020 Feb 4;35:100956. doi: 10.1016/j.molmet.2020.01.020

Figure 6.

Figure 6

Histaminergic neurons modulate the anorexigenic effects of MTII. A) Whole-cell current clamp recording showing CNO-induced hyperpolarization and inhibition of a HDC expressing cell from a Hdc-Cre::hM4Di mice mouse. B) Left: Cumulative food intake across the night was significantly different between the groups studied. Right: Hourly analysis of cumulate food intake (up to 6hrs post food return) showed MTII significantly reduced food intake in control animals and this effect was significantly enhanced when HDC neurons were inhibited. C) Left: Cumulative locomotor activity across the night was significantly different between the groups studied. Right: Hourly analysis of cumulative locomotor activity (up to 6hrs post food return) showed MTII had no effect on locomotor activity in control animals but was significantly reduced with MTII by 5hrs when HDC neurons were inhibited. Note: // denotes discontinuity (of 40sec) in the recording where current voltage relations were performed. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001 for comparisons between aCSF and MTII treated animals of the same genotype and #p < 0.05, ##p < 0.01 for comparisons between MTII treated hM4Di and Hdc-Cre::hM4Di animals.