Supplementary Figure 1.

Gut characterization in PTP1B WT and PTP1B KO mice under NASH conditions. A) Graph represents the ratio colon weight/length for body weight. White and black bars represent animals fed a chow or MCD diet, respectively. n= 5-7 mice per experimental group. B) Upper panel shows quantification of number of feces in the colon from the four experimental animal groups. Lower panel shows representative images of colon samples. n= 4-8 mice per experimental group. C) Feces humidity was measured with the moisture analyzer MB120 (Ohaus). Percentage of humidity was calculated from the difference between final dried feces and starting fresh feces. Data are expressed as mean ± SEM. n=6-11 mice per experimental group. ∗p<0.05; ∗∗p<0.01 PTP1B WT chow vs PTP1B WT MCD diet; ^##p<0.01; ^###p<0. 001 PTP1B KO chow vs PTP1B KO MCD.