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. 2020 Feb 6;35:100954. doi: 10.1016/j.molmet.2020.01.018

Figure 5.

Figure 5

mRNA expression levels of pro-inflammatory markers in colon samples of PTP1B WT and PTP1B KO mice during NASH. A-E) Cd3g (T-cell surface glycoprotein CD3 γ), GzmB (granzyme B), Ifng (interferon gamma), Nos2 (inducible nitric oxide synthase), and Ptp1n (PTP1B) mRNA levels are shown as fold change referred to the control PTP1B WT fed a chow diet. White dots correspond to mice fed a chow diet and black dots to mice fed a MCD diet during 4 weeks. Data are expressed as mean ± SEM. n = 5–10 mice per experimental group. ∗∗∗p < 0.001 PTP1B WT chow vs PTP1B WT MCD; ##p < 0.01 PTP1B KO chow vs PTP1B KO MCD; +p < 0.05; ++ p< 0.01; +++p < 0.001 PTP1B WT MCD vs PTP1B KO MCD.