Table 1.

Changes in gut microbiota composition at different taxonomic levels during NASH in PTP1B WT and PTP1B KO mice.

¹Comparison between the different conditions. Two-way ANOVA with a Tukey post-hoc test was performed for statistical analysis. ^aChanges in gut microbiota due to the administered diet. ↑ expresses higher abundance and ↓ indicates lower abundance after 4 weeks of MCD diet relative to chow diet. ^bChanges in gut microbiota due to the genotype. ↑ indicates higher and ↓ indicates lower abundance in PTP1B KO mice vs PTP1B WT mice. Taxa with differences due to diet and genotype are shown highlighted in purple. w refers to significant differences found only for PTP1B WT animals; k refers to significant differences found only for PTP1B KO animals. m refers to significant differences found only in MCD-fed animals. ^∗p<0.05; ^∗∗p<0,01; ^∗∗∗p<0.001. n=5-7 animals per condition.