Figure 1.

Principle component analysis (PCA) and heat map for differentially expressed genes in brains of multiple sclerosis (MS) patients compared to healthy brains obtained from publicly available RNAseq data (GSE123496). (A) Differential principle component log fold analysis of gene samples clustered in MS patients in different brain regions (red dots) versus those expressed in normal healthy individuals brains (NL) represented with blue dots. (B) Heat map performed on publicly available RNAseq data (GSE123496). Differential analysis showed clearly that top genes that are upregulated in MS compared to healthy individuals were related to immune cells. Three gene clusters were observed; immune cells and their regulators are accumulated in cluster 1.

Abbreviations: PC 1,2, principle component 1,2; MS, multiple sclerosis; NL, normal individuals.