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. 2020 Mar 10;15:1677–1691. doi: 10.2147/IJN.S225807

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© 2020 Hei et al.

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Biodistribution of free DiR, DiR@SSLs, and DiR@aPDL1-SSLs.

Notes: (A) In vivo fluorescence images of B16-F10 tumor-bearing mice after intravenous injection of the three formulations at 1, 2, 4, 8, 12, and 24 h (red circle represents the tumor area). (B) Ex vivo fluorescence images and (C) quantitative results of fluorescence efficiency of main organs and tumor tissues of the three groups 24 h after injection. (n = 3, results are shown as means ± S.D. ***P < 0.001.)

Abbreviations: DiR, 1,1-dioctadecyl-3,3,3,3-tetramethylindotricarbocyanine; DiR@SSLs, DiR-loaded liposomes; DiR@aPDL1-SSLs,DiR- loaded immunoliposomes.