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. 2020 Mar 10;15:1677–1691. doi: 10.2147/IJN.S225807

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© 2020 Hei et al.

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Effects of control (PBS), aPDL1-SSLs, CAT@SSLs, and CAT@aPDL1-SSLs on tumor hypoxia status.

Notes: (A) Immunofluorescence images of tumor slices harvested from B16-F10 tumor-bearing mice following intravenous injection with four different formulations. The blue signals represent nuclei stained by DAPI and the green signals represent hypoxia areas stained by hypoxia probe, respectively. (B) The quantitative results of positive tumor hypoxia areas analyzed using Image J software based on the images shown in (A). (n = 3, results are means ± S.D., Scale bar: 100 μm,*P < 0.05)

Abbreviations: aPDL1, programmed death ligand 1 monoclonal antibody; CAT, catalase; SSL, sterically stabilized liposome; aPDL1-SSLs, aPDL1 modified immunoliposomes; CAT@aPDL1-SSLs, CAT-loaded immunoliposomes.