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. 2020 Mar 10;15:1677–1691. doi: 10.2147/IJN.S225807

Figure 9.

Figure 9

Safety assessment of different formulations in vivo.

Notes: The morphology of the main organs, including the heart, liver, spleen, lungs, and kidneys were observed using the H&E staining method after treating mice with PBS, free aPDL1, SSLs, aPDL1-SSLs, CAT@SSLs, or CAT@aPDL1-SSLs (Scale bar: 100 μm).

Abbreviations: aPDL1, programmed death ligand 1 monoclonal antibody; CAT, catalase; SSL, sterically stabilized liposome; aPDL1-SSLs, aPDL1 modified immunoliposomes; CAT@aPDL1-SSLs, CAT-loaded immunoliposomes.