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. 2020 Mar 18;13(4):100751. doi: 10.1016/j.tranon.2020.100751

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© 2020 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

ENZ/AS602801 combination treatment in Luc-LNCaP xenografts. (A) Tumor growth of Luc-LNCaP xenografts treated with the indicated drugs for 25 days is presented. (B) Total body weight of mice is not affected by drug treatment. (C) Final tumor volume of the LNCaP xenograft tissues. (D) Final tumor weight of the LNCaP xenograft tissues. (E) Quantification of luciferase luminescence imaging before euthanasia of mice. (F) Immunohistochemistry of representative tumors stained for Ki67 to assess total proliferation. (G) Quantification of Ki67 IHC data. (H) Bioluminescence imaging of mice. Statistical analysis was performed with Student's t-test, *P < .05, **P < .01, ***P < .001. ****P < .0001.