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. 2020 Mar 18;13(4):100751. doi: 10.1016/j.tranon.2020.100751

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© 2020 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Nanostring analysis of AS602801 effects on LNCaP cells (A) Hierarchical clustering of 104 genes from nanostring mRNA signal data. LNCaP cells were treated with DMSO control, ENZ, AS602801, or combined AS602801/ENZ for 48 h and RNA harvested. One hundred four genes annotated for JNK, AR, or cell cycle (CC) pathways that were significantly different between AS602801-treated cells and controls were included in the cluster analysis. Gene symbols and the pathways for which each gene is annotated are indicated to the right. Red indicates increased mRNA and blue indicated decreased mRNA levels. (B) Subset of affected genes from hierarchical clustering. (C) Western blot for PARP in LNCaP cells indicates induction of apoptosis in AS602801-treated cells. (D) Similar blot for PARP in AS602801-treated C4-2 cells.