Table A21:

Scenario Analysis of Budget Impact Using Upper Estimate for Target Population

	Budget Impact, $ Milliona,b
Scenario	Year 1	Year 2	Year 3	Year 4	Year 5	Total
Total Cost of Current Scenario
Testing costs	4.17	4.17	4.17	4.17	4.17	20.84
Non-testing costs	80.24	124.24	145.12	156.27	162.12	668.00
Total	84.41	128.41	149.29	160.44	166.29	688.83
Total Cost of New Scenario 1 (Liquid Biopsy as Triage Test)
Testing costs	4.22	4.01	3.81	3.60	3.39	19.03
Non-testing costs	80.24	127.23	152.33	168.48	179.78	708.06
Total	84.46	131.25	156.14	172.07	183.17	727.09
Budget Impact of New Scenario 1 (Liquid Biopsy as Triage Test)
Testing costs	0.06	−0.15	−0.36	−0.57	−0.78	−1.81
Non-testing costs	0.00	2.99	7.21	12.21	17.66	40.06
Total	0.06	2.84	6.85	11.64	16.88	38.26
Total Cost of New Scenario 2 (Liquid Biopsy Alone)
Testing costs	3.84	3.23	2.63	2.02	1.42	13.15
Non-testing costs	78.25	122.30	143.87	156.13	163.37	663.92
Total	82.09	125.54	146.50	158.15	164.79	677.07
Budget Impact of New Scenario 2 (Liquid Biopsy Alone)
Testing costs	−0.33	−0.93	−1.54	−2.14	−2.75	−7.69
Non-testing costs	−1.98	−1.94	−1.25	−0.14	1.25	−4.07
Total	−2.31	−2.87	−2.79	−2.29	−1.50	−11.77

^aIn 2018 Canadian dollars.

^bNumbers could appear incorrect because of rounding.