Figure 5.

Displacement of [³H] (+) pentazocine from sigma-1 receptors by DTG. Competition binding curve showing the displacement of either 100 nM (filled squares) or 1 µM (open circles) [³H] (+) pentazocine from sigma-1 receptors in membranes prepared from MDA-MB-468 cells by increasing DTG concentrations. Non-specific binding was determined in the presence of 1 mM reduced haloperidol. Data represent mean ± SEM from 8 (100 nM [³H] (+) pentazocine) or 6 (1 µM [³H] (+) pentazocine) independent experiments.