Table 1.

Displacement of [³H] (+) pentazocine from sigma-1 receptors by increasing concentrations of DTG.

[[³H] (+) pentazocine]	[DTG] 3 nM	[DTG] 10 nM	[DTG] 30 nM	[DTG] 100 nM	[DTG] 300 nM
100 nM	2.5 ± 0.9	4.7 ± 1.6	8.6 ± 2.6	26.3 ± 9.9	37 ± 11
1 µM	2.9 ± 2.5	4.8 ± 3.9	7.6 ± 5.9	11.6 ± 8.2	17 ± 11

Data represent [³H] (+) pentazocine displaced by increasing concentrations of DTG (as % of binding in the absence of DTG). Data (mean ± SEM) are interpolated from individual competition curves, n = 8 (100 nM (+) pentazocine) and n = 6 (1 µM (+) pentazocine). Values are derived using the data presented in Figure 5 .